Specialized Peripheral Nerve Stimulation Systems for Inflammatory Bowel Disease Treatment in Extreme Environments

Publication ID: 24-11857778_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Specialized Peripheral Nerve Stimulation Systems for Inflammatory Bowel Disease Treatment in Extreme Environments,” Published Technical Disclosure No. 24-11857778_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857778_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,778.

Summary of the Inventive Concept

This inventive concept adapts peripheral nerve stimulation technology for treating inflammatory bowel disease to specific, challenging operational environments, such as high-altitude, disaster relief, high-security, extreme weather, and remote or rural areas.

Background and Problem Solved

The original patent for peripheral nerve stimulation systems for treating inflammatory bowel disease has limitations when applied to specific, niche environments. For instance, traditional systems may not be optimized for low-oxygen conditions, high-security settings, or remote areas with limited connectivity. This inventive concept addresses these limitations by developing specialized systems and methods tailored to these unique environments.

Detailed Description of the Inventive Concept

The new claims describe systems and methods for treating inflammatory bowel disease in various extreme environments. For example, Claim 1 describes a portable peripheral nerve stimulator adapted for use in low-oxygen conditions, with a power source optimized for extended battery life. Claim 2 details a method for treating symptoms of Crohn's disease in a disaster relief setting, utilizing real-time feedback from a vital signs monitor to adjust the electrical nerve stimulation signal. Similarly, Claim 3 describes a secure peripheral nerve stimulator with biometric authentication for high-security environments, while Claim 4 outlines a method for treating irritable bowel syndrome in extreme weather conditions, using real-time feedback from a weather monitoring system. Finally, Claim 5 presents a system for treating microscopic colitis in remote or rural areas, featuring a portable peripheral nerve stimulator with satellite connectivity and a telemedicine platform for remote consultation and treatment monitoring.

Novelty and Inventive Step

The new claims introduce novel and non-obvious adaptations of peripheral nerve stimulation technology for treating inflammatory bowel disease in extreme environments. These adaptations include the development of portable, low-oxygen optimized stimulators, secure stimulators with biometric authentication, and systems with real-time feedback from vital signs or weather monitoring systems. These innovations provide a significant improvement over traditional systems and enable effective treatment in challenging operational environments.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include specialized systems for treating other inflammatory diseases in extreme environments, such as rheumatoid arthritis in high-altitude settings or autoimmune hepatitis in disaster relief scenarios. Variations may also involve different types of sensors or monitoring systems, such as wearable devices or mobile applications, to provide real-time feedback and adjust the electrical nerve stimulation signal.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in various industries, including healthcare, disaster relief, and national security. The market for specialized peripheral nerve stimulation systems for treating inflammatory bowel disease in extreme environments is substantial, with potential customers including government agencies, non-profit organizations, and private companies operating in these environments.

Field of Art

Biomedical engineering, specifically peripheral nerve stimulation for treating inflammatory gastrointestinal diseases, requiring advanced understanding of electrical nerve stimulation, medical device design, and physiological signal modulation

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in neurostimulation techniques, electrical signal parameters, patient monitoring systems, and adaptive medical technology design

Obviousness Rationale

A person having ordinary skill in the art would recognize that the PTD's variations represent predictable extensions of the source patent's core peripheral nerve stimulation methodology by applying known engineering adaptation techniques to specific environmental contexts. The fundamental nerve stimulation approach remains consistent, with the primary innovation being contextual optimization rather than fundamental technological transformation. These variations demonstrate standard engineering problem-solving approaches of adapting existing medical technologies to specialized use cases.

Obvious Combinations & Variations

Source Patent Element
Transcutaneous peripheral nerve stimulation for inflammatory gastrointestinal disease treatment
PTD Variation
Portable peripheral nerve stimulator adapted for high-altitude, low-oxygen environments with extended battery life
Obviousness Reasoning
Adapting medical devices for environmental constraints represents a predictable design optimization using known engineering techniques, with battery and power management being standard engineering challenges
Source Patent Element
Electrical nerve stimulation signal delivered transcutaneously
PTD Variation
Real-time signal adjustment based on vital signs or environmental monitoring feedback
Obviousness Reasoning
Integrating adaptive feedback mechanisms is a known technique in medical device design, representing a predictable enhancement to improve treatment precision and patient safety
Source Patent Element
Peripheral nerve effector positioned on patient's skin
PTD Variation
Secure peripheral nerve stimulator with biometric authentication for high-security environments
Obviousness Reasoning
Adding security features through authentication technologies represents a standard design choice for medical devices, utilizing well-established access control methodologies
Source Patent Element
Electrical stimulation of specific nerve fiber types
PTD Variation
Telemedicine platform for remote consultation and treatment monitoring in rural areas
Obviousness Reasoning
Extending medical device functionality through telecommunications is a predictable technological progression, leveraging standard communication and monitoring technologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857778 and the disclosed variations, a person having ordinary skill in the art would find the claimed peripheral nerve stimulation adaptations for extreme environments obvious and lacking inventive step. The PTD demonstrates that the core nerve stimulation methodology can be readily modified through standard engineering techniques to address specific contextual requirements, thereby rendering potential claims in this domain obvious and non-patentable.

Original Patent Information

Patent NumberUS 11,857,778
TitleSystems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
Assignee(s)Cala Health, Inc.