Synergistic Combinations for Enhanced Inflammatory Bowel Disease Treatment

Publication ID: 24-11857778_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Combinations for Enhanced Inflammatory Bowel Disease Treatment,” Published Technical Disclosure No. 24-11857778_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857778_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,778.

Summary of the Inventive Concept

Integrating peripheral nerve stimulation with AI, IoT, blockchain, and new materials to create a more effective and personalized treatment system for inflammatory bowel disease.

Background and Problem Solved

The original patent disclosed systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation. However, these methods have limitations in terms of data management, predictive analytics, and personalized treatment. The new inventive concept addresses these limitations by combining peripheral nerve stimulation with emerging technologies to create a more comprehensive and effective treatment system.

Detailed Description of the Inventive Concept

The new inventive concept consists of a peripheral nerve stimulator configured to modulate autonomic tone, which is integrated with a blockchain-based patient data management module for secure data storage and sharing. An AI-powered predictive analytics engine optimizes stimulation parameters based on patient response. Additionally, the system may include an IoT-enabled sensor module for monitoring physiological parameters and a cloud-based AI platform for analyzing sensor data and adjusting stimulation parameters. Alternatively, a new material-based implantable device can be used for delivering electrical stimulation signals. The synergistic combination of these technologies enables a more personalized and effective treatment approach.

Novelty and Inventive Step

The new claims introduce the novel combination of peripheral nerve stimulation with AI, IoT, blockchain, and new materials, which provides a significant improvement over the original patent. The integration of these technologies enables a more comprehensive and personalized treatment system, which is not obvious from the original patent.

Alternative Embodiments and Variations

Other embodiments of the inventive concept may include using different types of sensors or data analytics platforms, integrating with electronic health records, or incorporating machine learning algorithms for predictive modeling. Variations may also include using different materials or implantable devices, or incorporating additional features such as patient feedback mechanisms or remote monitoring capabilities.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the treatment of inflammatory bowel disease, with potential applications in personalized medicine, telehealth, and digital therapeutics. The target market includes pharmaceutical companies, medical device manufacturers, and healthcare providers seeking innovative solutions for chronic disease management.

Original Patent Information

Patent NumberUS 11,857,778
TitleSystems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
Assignee(s)Cala Health, Inc.