Advanced Implantable and Non-Invasive Stimulators for Enhanced Gastrointestinal Therapeutics

Publication ID: 24-11857783_0001_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Implantable and Non-Invasive Stimulators for Enhanced Gastrointestinal Therapeutics,” Published Technical Disclosure No. 24-11857783_0001_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857783_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,783.

Summary of the Inventive Concept

This inventive concept discloses advanced implantable and non-invasive stimulators that provide real-time feedback, personalized stimulation therapy, and improved gastrointestinal motility regulation, thereby enhancing the treatment of gastrointestinal dysmotility and related disorders.

Background and Problem Solved

The original patent, 'Implantable and non-invasive stimulators for gastrointestinal therapeutics', provides a foundation for gastrointestinal stimulation. However, it has limitations in terms of providing real-time feedback, personalization, and precise control over stimulation parameters. The new inventive concept addresses these limitations by integrating advanced sensors, miniaturized implants, and user interfaces to provide more effective and efficient gastrointestinal stimulation.

Detailed Description of the Inventive Concept

The advanced stimulators comprise miniaturized implants with integrated power sources and sensors for detecting gastrointestinal motility. These implants provide real-time feedback to users, enabling optimization of stimulation parameters. Non-invasive transcutaneous stimulators are also integrated with wearable sensors to detect gastrointestinal motility, providing personalized stimulation therapy. The system can be controlled by user interfaces, such as mobile devices, to receive input from users and adjust stimulation accordingly. Additionally, the stimulators can be disposable and rechargeable, reducing the need for frequent replacements.

Novelty and Inventive Step

The new claims introduce the concept of real-time feedback, personalized stimulation therapy, and improved gastrointestinal motility regulation, which are not present in the original patent. The integration of advanced sensors, miniaturized implants, and user interfaces provides a novel and non-obvious solution to the limitations of the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different types of sensors, such as impedance sensors or pH sensors, to detect gastrointestinal motility. Variations may also include the integration of artificial intelligence algorithms to optimize stimulation parameters based on user feedback and physiological signals.

Potential Commercial Applications and Market

The advanced implantable and non-invasive stimulators have significant commercial potential in the treatment of gastrointestinal dysmotility and related disorders, such as irritable bowel syndrome, gastroparesis, and inflammatory bowel disease. The target market includes medical device companies, hospitals, and healthcare providers specializing in gastrointestinal care.

Field of Art

Biomedical engineering, specifically gastrointestinal stimulation technologies, focusing on electrical neurostimulation systems for treating gastrointestinal disorders

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in electrical stimulation, neural interface technologies, and medical device miniaturization, holding advanced degrees in bioengineering or electrical engineering with 3-5 years of experience in medical device development

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core technology by adding known sensor integration, feedback mechanisms, and user interface controls to existing electrical stimulation approaches for gastrointestinal therapeutics. The incremental improvements in miniaturization, real-time monitoring, and personalized stimulation would be considered obvious refinements within the established technological framework of neural stimulation systems.

Obvious Combinations & Variations

Source Patent Element
Transcutaneous stimulator with array of independently addressable electrodes
PTD Variation
Miniaturized implantable stimulator with integrated power source and sensor for detecting gastrointestinal motility
Obviousness Reasoning
Miniaturization of electrical stimulation devices is a predictable design evolution, and integrating sensors for real-time feedback represents a known technique for improving medical device functionality
Source Patent Element
Mobile device control of stimulation parameters
PTD Variation
User interface with AI-driven optimization of stimulation parameters based on physiological signals
Obviousness Reasoning
Adaptive control systems and machine learning integration are well-established approaches for optimizing medical device performance, representing an obvious technological progression
Source Patent Element
Electrode array positioned on patient's skin or abdomen
PTD Variation
Non-invasive transcutaneous stimulator combined with wearable sensors for personalized stimulation therapy
Obviousness Reasoning
Combining wearable sensor technologies with existing stimulation approaches is a predictable solution for enhancing medical device functionality and patient monitoring
Source Patent Element
Electrical field directed through spinal ganglions to modulate neural activity
PTD Variation
Direct stimulation of enteric nervous system, ICCs, and vagus nerve branches with real-time monitoring
Obviousness Reasoning
Exploring alternative neural stimulation targets within the same physiological system represents a routine design variation for medical device engineers
Source Patent Element
Electrical stimulation system with mobile device integration
PTD Variation
Disposable rechargeable stimulator with system-on-a-chip (SoC) for current mode stimulation
Obviousness Reasoning
Implementing advanced microelectronics and creating disposable medical devices are predictable technological improvements driven by miniaturization and cost-reduction trends
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857783 and the disclosed variations, a person of ordinary skill in the art would find the claimed innovations obvious, as they represent predictable technological extensions utilizing known techniques in electrical stimulation, sensor integration, and medical device design. The incremental improvements in miniaturization, personalized therapy, and real-time monitoring would be considered routine design choices within the established technological framework of gastrointestinal stimulation systems.

Original Patent Information

Patent NumberUS 11,857,783
TitleImplantable and non-invasive stimulators for gastrointestinal therapeutics
Assignee(s)The Regents of the University of California