Personalized Real-time Adaptive Cavitation-Enhanced Ultrasound Treatment Planning

Publication ID: 24-11857807_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Real-time Adaptive Cavitation-Enhanced Ultrasound Treatment Planning,” Published Technical Disclosure No. 24-11857807_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857807_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,807.

Summary of the Inventive Concept

A next-generation system for cavitation-enhanced ultrasound treatment planning that integrates real-time monitoring, AI-driven optimization, and personalized treatment protocols to revolutionize drug delivery and treatment outcomes.

Background and Problem Solved

The original patent disclosed a simulation-based drug treatment planning system, but it had limitations in terms of real-time adaptability and personalized treatment. The new inventive concept addresses these limitations by introducing a wearable implantable device, neural network-based AI module, and digital twin modeling to enable real-time adaptive drug delivery and closed-loop control.

Detailed Description of the Inventive Concept

The inventive concept comprises a wearable implantable device that monitors a patient's physiological responses to a cavitation-enhanced ultrasound procedure and adjusts sonication parameters in real-time. The device is integrated with a neural network-based AI module that predicts optimal sonication parameters based on real-time data from the patient's physiological responses. Additionally, the system utilizes a digital twin model of the patient's anatomy and a machine learning-based optimization engine to predict optimal treatment protocols for individual patients. The system enables personalized, closed-loop control of the ultrasound procedure, ensuring optimal treatment outcomes and minimizing adverse effects.

Novelty and Inventive Step

The new inventive concept introduces the novel combination of real-time monitoring, AI-driven optimization, and digital twin modeling to enable personalized and adaptive cavitation-enhanced ultrasound treatment planning. This represents a significant departure from the original patent's simulation-based approach and provides a paradigm shift in the field of drug treatment planning.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of sensors, AI algorithms, or optimization engines. Variations could also include the integration of additional data sources, such as medical imaging or genomic data, to further personalize treatment protocols.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and medical device industries, particularly in the areas of targeted drug delivery and personalized medicine. The system could be marketed as a platform for optimizing treatment outcomes and reducing adverse effects in a variety of therapeutic applications.

Original Patent Information

Patent NumberUS 11,857,807
TitleSimulation-based drug treatment planning
Assignee(s)INSIGHTEC, LTD.