Personalized Real-time Adaptive Cavitation-Enhanced Ultrasound Treatment Planning
Legal Citation
Summary of the Inventive Concept
A next-generation system for cavitation-enhanced ultrasound treatment planning that integrates real-time monitoring, AI-driven optimization, and personalized treatment protocols to revolutionize drug delivery and treatment outcomes.
Background and Problem Solved
The original patent disclosed a simulation-based drug treatment planning system, but it had limitations in terms of real-time adaptability and personalized treatment. The new inventive concept addresses these limitations by introducing a wearable implantable device, neural network-based AI module, and digital twin modeling to enable real-time adaptive drug delivery and closed-loop control.
Detailed Description of the Inventive Concept
The inventive concept comprises a wearable implantable device that monitors a patient's physiological responses to a cavitation-enhanced ultrasound procedure and adjusts sonication parameters in real-time. The device is integrated with a neural network-based AI module that predicts optimal sonication parameters based on real-time data from the patient's physiological responses. Additionally, the system utilizes a digital twin model of the patient's anatomy and a machine learning-based optimization engine to predict optimal treatment protocols for individual patients. The system enables personalized, closed-loop control of the ultrasound procedure, ensuring optimal treatment outcomes and minimizing adverse effects.
Novelty and Inventive Step
The new inventive concept introduces the novel combination of real-time monitoring, AI-driven optimization, and digital twin modeling to enable personalized and adaptive cavitation-enhanced ultrasound treatment planning. This represents a significant departure from the original patent's simulation-based approach and provides a paradigm shift in the field of drug treatment planning.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different types of sensors, AI algorithms, or optimization engines. Variations could also include the integration of additional data sources, such as medical imaging or genomic data, to further personalize treatment protocols.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the pharmaceutical and medical device industries, particularly in the areas of targeted drug delivery and personalized medicine. The system could be marketed as a platform for optimizing treatment outcomes and reducing adverse effects in a variety of therapeutic applications.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Medical device engineering, biomedical ultrasound technologies, and drug delivery systems with a focus on blood-brain barrier treatment and personalized medical interventions
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or medical device researcher with advanced degrees in bioengineering, expertise in ultrasound technologies, machine learning applications in medical treatments, and familiarity with adaptive medical device design
Obviousness Rationale
A PHOSITA would recognize that the PTD's proposed real-time adaptive system represents a natural evolutionary progression from the source patent's simulation-based approach. The integration of AI-driven optimization and real-time monitoring are logical extensions of the original patent's predictive modeling and treatment adjustment framework. The core technical problem of precise ultrasound-mediated drug delivery remains consistent, with the PTD offering incremental technological improvements using standard machine learning and sensor integration techniques.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,807 |
|---|---|
| Title | Simulation-based drug treatment planning |
| Assignee(s) | INSIGHTEC, LTD. |