Particle Therapy for Diverse Medical Applications

Publication ID: 24-11857808_0007_PTD

Published: October 28, 2025

Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Particle Therapy for Diverse Medical Applications,” Published Technical Disclosure No. 24-11857808_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857808_0007_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,808.

Summary of the Inventive Concept

This inventive concept leverages the core technology of particle therapy to address a range of medical conditions beyond cardiac arrhythmias, including neurological disorders, cancer treatment, kidney stone removal, spinal cord injuries, and age-related macular degeneration.

Background and Problem Solved

The original patent disclosed a system and method for carbon particle therapy for treatment of cardiac arrhythmias and other diseases. However, the patent's focus on cardiac arrhythmias limited its application to other medical conditions. This inventive concept addresses the need for a more versatile particle therapy system capable of treating diverse medical conditions, overcoming the limitations of the original patent.

Detailed Description of the Inventive Concept

The new claims expand the application of particle therapy to various medical fields. For instance, Claim 1 proposes a system for treating neurological disorders using real-time imaging and gating to compensate for brain movement during treatment. Claim 2 describes a method for treating cancerous tumors in the liver using contouring to identify and track the tumor through multiple treatment sessions. Similarly, Claims 3-5 outline devices and methods for treating kidney stones, spinal cord injuries, and age-related macular degeneration, respectively, each utilizing unique adaptations of the particle therapy system.

Novelty and Inventive Step

The new claims introduce novel applications of particle therapy, including the use of real-time imaging, gating, and contouring to compensate for movement in various medical contexts. These adaptations constitute a non-obvious extension of the original patent, demonstrating a significant inventive step.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of particles, such as protons or heavy ions, or the integration of artificial intelligence algorithms to optimize treatment planning and delivery. Variations could also involve the development of portable or compact particle therapy systems for increased accessibility.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the medical industry, with potential applications in neurology, oncology, urology, orthopedics, and ophthalmology. The market for particle therapy systems is expected to grow as the technology becomes more widely adopted, offering a substantial opportunity for companies and researchers to develop and commercialize these innovative solutions.

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Medical particle therapy, specifically focused on targeted atomic particle delivery for therapeutic interventions across multiple medical specialties including cardiology, neurology, oncology, and ophthalmology

Person of Ordinary Skill (PHOSITA) Profile

A medical physicist or biomedical engineer with advanced training in particle accelerator technologies, radiation therapy techniques, medical imaging, and treatment planning systems with expertise in real-time tracking and compensation for tissue movement

Obviousness Rationale

A person having ordinary skill in the art would recognize that the core particle therapy methodology disclosed in US 11857808 for cardiac arrhythmias represents a generalizable approach that can be systematically adapted to other medical conditions by applying consistent technical strategies of real-time imaging, gating, and phase contouring to compensate for tissue movement. The fundamental technical principles of particle delivery, movement tracking, and precision targeting are directly transferable across different anatomical contexts. A PHOSITA would understand that the specific implementation details can be modified based on the unique characteristics of each targeted tissue while maintaining the underlying technological framework.

Obvious Combinations & Variations

Source Patent Element

Mapping targeted tissue to compensate for respiratory and cardiac movements during particle delivery

PTD Variation

Applying identical movement compensation techniques to brain, liver, kidney, spinal cord, and retinal treatments

Obviousness Reasoning

Known technique of movement tracking is universally applicable across anatomical systems, representing a predictable extension of the original technological approach

Source Patent Element

Using gating to synchronize particle delivery with tissue movement

PTD Variation

Implementing gating protocols for neurological and spinal cord treatments to manage tissue displacement

Obviousness Reasoning

Gating is a standard technique in precision radiation therapy, and its application to different anatomical regions would be an obvious design choice for a skilled practitioner

Source Patent Element

Phase contouring using pre-procedural imaging to obtain sequential images

PTD Variation

Extending phase contouring methodology to track tumors, kidney stones, and retinal structures during treatment

Obviousness Reasoning

The fundamental image-based tracking methodology is technically consistent across different medical contexts, representing a straightforward technological adaptation

Source Patent Element

Delivery of accelerated atomic particles to targeted tissue regions

PTD Variation

Expanding particle delivery techniques to diverse medical conditions beyond cardiac interventions

Obviousness Reasoning

The core particle therapy technology represents a generalizable medical intervention strategy that can be systematically applied to multiple therapeutic contexts with predictable modifications

Source Patent Element

Avoiding non-targeted tissue surrounding critical targets

PTD Variation

Implementing precision targeting protocols for neurological, oncological, and ophthalmological treatments

Obviousness Reasoning

Tissue-sparing techniques are a standard consideration in radiation therapy, and their application across different medical specialties would be an obvious extension of established medical engineering principles

35 U.S.C. § 103 Summary: Based on the teachings of US 11857808, a person having ordinary skill in the art would find the variations disclosed herein to be obvious extensions of the fundamental particle therapy methodology, as the core technical strategies of movement tracking, precision targeting, and adaptive imaging are directly transferable across multiple medical contexts through routine engineering adaptations that would be apparent to a skilled practitioner in the field.

Original Patent Information

Patent Number	US 11,857,808
Title	System and method for carbon particle therapy for treatment of cardiac arrhythmias and other diseases
Assignee(s)	Mayo Foundation for Medical Education and Research