Sonogenic Stimulation for Diverse Applications

Publication ID: 24-11857809_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Sonogenic Stimulation for Diverse Applications,” Published Technical Disclosure No. 24-11857809_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857809_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,809.

Summary of the Inventive Concept

Expanding the core technology of sonogenic stimulation to treat cancer, enhance athletic performance, monitor cardiac activity, treat neurological disorders, and rejuvenate skin, by applying ultrasound energy to targeted cells expressing TRP-4 polypeptide.

Background and Problem Solved

The original patent, 'Sonogenic stimulation of cells', focused on altering the function or activity of neurons in a mammalian subject. However, this invention is limited to neural applications. The new inventive concept addresses the need for a broader range of applications, leveraging the core technology to tackle diverse challenges in cancer treatment, athletic performance, cardiac monitoring, neurological disorders, and skin rejuvenation.

Detailed Description of the Inventive Concept

The new inventive concept comprises a sonogenic stimulation device configured to apply ultrasound energy to targeted cells expressing TRP-4 polypeptide. In cancer treatment, the device induces apoptosis in tumor cells. For athletic performance, it enhances muscle contraction force by stimulating muscle cells. In cardiac monitoring, it generates an electrical signal indicative of cardiac activity. For neurological disorders, it modulates neural activity. Finally, in skin rejuvenation, it increases collagen production in skin cells. The TRP-4 polypeptide is a crucial component, as it is activated by ultrasound energy to produce the desired effects.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious because it applies the core technology of sonogenic stimulation to entirely new fields and use cases, which were not considered in the original patent. The inventive step lies in the recognition of the potential for sonogenic stimulation to address diverse challenges beyond neural applications.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include varying the type of cells targeted, the specific TRP polypeptide used, or the frequency and intensity of the ultrasound energy. Additionally, the device could be designed for implantation, wearable use, or handheld application.

Potential Commercial Applications and Market

The new inventive concept has significant commercial potential in the fields of oncology, sports medicine, cardiology, neurology, and cosmetics. The market for such applications is substantial, with potential customers including hospitals, clinics, research institutions, and individual consumers.

Original Patent Information

Patent NumberUS 11,857,809
TitleSonogenic stimulation of cells
Assignee(s)Salk Institute for Biological Studies