Sonogenic Stimulation for Diverse Applications

Publication ID: 24-11857809_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Sonogenic Stimulation for Diverse Applications,” Published Technical Disclosure No. 24-11857809_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857809_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,809.

Summary of the Inventive Concept

Expanding the core technology of sonogenic stimulation to treat cancer, enhance athletic performance, monitor cardiac activity, treat neurological disorders, and rejuvenate skin, by applying ultrasound energy to targeted cells expressing TRP-4 polypeptide.

Background and Problem Solved

The original patent, 'Sonogenic stimulation of cells', focused on altering the function or activity of neurons in a mammalian subject. However, this invention is limited to neural applications. The new inventive concept addresses the need for a broader range of applications, leveraging the core technology to tackle diverse challenges in cancer treatment, athletic performance, cardiac monitoring, neurological disorders, and skin rejuvenation.

Detailed Description of the Inventive Concept

The new inventive concept comprises a sonogenic stimulation device configured to apply ultrasound energy to targeted cells expressing TRP-4 polypeptide. In cancer treatment, the device induces apoptosis in tumor cells. For athletic performance, it enhances muscle contraction force by stimulating muscle cells. In cardiac monitoring, it generates an electrical signal indicative of cardiac activity. For neurological disorders, it modulates neural activity. Finally, in skin rejuvenation, it increases collagen production in skin cells. The TRP-4 polypeptide is a crucial component, as it is activated by ultrasound energy to produce the desired effects.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious because it applies the core technology of sonogenic stimulation to entirely new fields and use cases, which were not considered in the original patent. The inventive step lies in the recognition of the potential for sonogenic stimulation to address diverse challenges beyond neural applications.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include varying the type of cells targeted, the specific TRP polypeptide used, or the frequency and intensity of the ultrasound energy. Additionally, the device could be designed for implantation, wearable use, or handheld application.

Potential Commercial Applications and Market

The new inventive concept has significant commercial potential in the fields of oncology, sports medicine, cardiology, neurology, and cosmetics. The market for such applications is substantial, with potential customers including hospitals, clinics, research institutions, and individual consumers.

Field of Art

Biomedical engineering, neuroscience, and cellular stimulation technologies, with expertise in ultrasound-based cellular modulation and genetic engineering of ion channel proteins

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in bioengineering or neuroscience, familiar with genetic modification techniques, ultrasound technologies, and cellular signal transduction mechanisms

Obviousness Rationale

A PHOSITA would recognize that the core mechanism of ultrasound-activated TRP-4 protein from the source patent provides a versatile platform for cellular manipulation across multiple biological systems. The fundamental principle of using ultrasound to activate genetically modified proteins is directly transferable to diverse cellular contexts. The PTD's variations represent predictable extensions of the original sonogenic stimulation concept by applying the established ultrasound-protein interaction to different tissue types and therapeutic objectives.

Obvious Combinations & Variations

Source Patent Element
Ultrasound-activated neural stimulation using TRP-4 protein
PTD Variation
Applying ultrasound stimulation to muscle cells for performance enhancement
Obviousness Reasoning
Predictable extension of cellular activation technique to a closely related excitable tissue type with known responsiveness to electrical/mechanical stimulation
Source Patent Element
Genetic modification of neurons to express ultrasound-sensitive proteins
PTD Variation
Genetic modification of cancer cells to enable ultrasound-induced apoptosis
Obviousness Reasoning
Known technique of targeted cellular modification applied to a different cellular context with a predictable outcome of controlled cell death
Source Patent Element
Ultrasound energy application to targeted tissue portions
PTD Variation
Non-invasive cardiac activity monitoring using ultrasound-activated TRP-4 proteins
Obviousness Reasoning
Logical adaptation of existing signal transduction mechanism to create a diagnostic monitoring technique using established cellular activation principles
Source Patent Element
Modulation of neural activity through ultrasound-sensitive proteins
PTD Variation
Neurological disorder treatment by modulating neural cell activity
Obviousness Reasoning
Direct clinical translation of existing neural stimulation mechanism to address pathological neural conditions
Source Patent Element
Transmembrane protein activation by ultrasound energy
PTD Variation
Skin cell collagen production stimulation through ultrasound-activated TRP-4 proteins
Obviousness Reasoning
Predictable application of cellular activation technique to stimulate specific cellular metabolic processes using known signal transduction principles
35 U.S.C. § 103 Summary: Based on US Patent 11857809's disclosure of sonogenic stimulation using ultrasound-activated TRP-4 proteins, the present publication demonstrates that a person of ordinary skill in the art would find the disclosed variations obvious through predictable extension of the fundamental cellular activation mechanism to diverse biological contexts. The variations represent routine application of known ultrasound-protein interaction principles to alternative tissue types and therapeutic objectives, thereby rendering potential claims in this domain obvious and anticipatable.

Original Patent Information

Patent NumberUS 11,857,809
TitleSonogenic stimulation of cells
Assignee(s)Salk Institute for Biological Studies