Synergistic Sonogenic Stimulation Systems
Legal Citation
Summary of the Inventive Concept
The present inventive concept integrates sonogenic stimulation with AI, IoT, blockchain, and novel materials to create more effective and personalized therapies for neurological disorders.
Background and Problem Solved
The original patent disclosed a method for altering neuron function using sonogenic stimulation. However, the method had limitations in terms of precision, efficacy, and data management. The present inventive concept addresses these limitations by incorporating advanced technologies to enhance the sonogenic stimulation method.
Detailed Description of the Inventive Concept
The inventive concept encompasses four main embodiments. The first embodiment is a system that combines a neuron-specific TRP-4 polypeptide expression vector with an ultrasound transducer and a machine learning algorithm for predicting optimal ultrasound stimulation parameters. The second embodiment is a method that uses blockchain technology to securely store and analyze neuron activity data in conjunction with sonogenic stimulation. The third embodiment is a composition that incorporates a TRP-4 polypeptide, an ultrasound-responsive nanoparticle, and an AI-powered ultrasound controller for real-time optimization of ultrasound stimulation parameters. The fourth embodiment is a non-invasive system that utilizes a wearable IoT device for transmitting ultrasound energy and a cloud-based AI platform for analyzing neuron activity data and providing personalized treatment recommendations. The inventive concept also contemplates the use of synergistic combinations of ultrasound and other stimulation modalities, optimized using deep learning algorithms.
Novelty and Inventive Step
The present inventive concept is novel and non-obvious in its integration of sonogenic stimulation with advanced technologies such as AI, IoT, blockchain, and novel materials. The inventive concept's use of machine learning algorithms, blockchain technology, and AI-powered ultrasound controllers provides a significant improvement over the original patent's method.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept may include the use of different types of AI algorithms, such as reinforcement learning or natural language processing, or the incorporation of additional sensors or data sources to enhance the precision of the sonogenic stimulation method. Variations of the inventive concept may also include the use of different types of nanoparticles or ultrasound-responsive materials.
Potential Commercial Applications and Market
The present inventive concept has significant commercial potential in the treatment of neurological disorders such as Parkinson's disease, epilepsy, and depression. The market for neurological disorder treatments is projected to grow significantly in the coming years, and the inventive concept's ability to provide personalized and effective therapies positions it for success in this market.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Neuroscience, biomedical engineering, and molecular biology, with expertise in neural stimulation techniques, genetic modification of neurons, and ultrasound-based cellular manipulation
Person of Ordinary Skill (PHOSITA) Profile
A researcher or engineer with advanced degrees in neuroscience or bioengineering, familiar with genetic modification techniques, ultrasound technologies, and computational approaches to neural stimulation
Obviousness Rationale
A person of ordinary skill would recognize that integrating computational technologies with the source patent's sonogenic stimulation method represents a predictable extension of existing neural manipulation techniques. The core ultrasound-based neuronal stimulation method remains fundamentally unchanged, with added computational layers that a skilled practitioner would view as standard optimization approaches. The PTD's variations primarily represent well-known technological augmentations to an existing precise neurological intervention method.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,809 |
|---|---|
| Title | Sonogenic stimulation of cells |
| Assignee(s) | Salk Institute for Biological Studies |