Synergistic Sonogenic Stimulation Systems

Publication ID: 24-11857809_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Sonogenic Stimulation Systems,” Published Technical Disclosure No. 24-11857809_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857809_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,809.

Summary of the Inventive Concept

The present inventive concept integrates sonogenic stimulation with AI, IoT, blockchain, and novel materials to create more effective and personalized therapies for neurological disorders.

Background and Problem Solved

The original patent disclosed a method for altering neuron function using sonogenic stimulation. However, the method had limitations in terms of precision, efficacy, and data management. The present inventive concept addresses these limitations by incorporating advanced technologies to enhance the sonogenic stimulation method.

Detailed Description of the Inventive Concept

The inventive concept encompasses four main embodiments. The first embodiment is a system that combines a neuron-specific TRP-4 polypeptide expression vector with an ultrasound transducer and a machine learning algorithm for predicting optimal ultrasound stimulation parameters. The second embodiment is a method that uses blockchain technology to securely store and analyze neuron activity data in conjunction with sonogenic stimulation. The third embodiment is a composition that incorporates a TRP-4 polypeptide, an ultrasound-responsive nanoparticle, and an AI-powered ultrasound controller for real-time optimization of ultrasound stimulation parameters. The fourth embodiment is a non-invasive system that utilizes a wearable IoT device for transmitting ultrasound energy and a cloud-based AI platform for analyzing neuron activity data and providing personalized treatment recommendations. The inventive concept also contemplates the use of synergistic combinations of ultrasound and other stimulation modalities, optimized using deep learning algorithms.

Novelty and Inventive Step

The present inventive concept is novel and non-obvious in its integration of sonogenic stimulation with advanced technologies such as AI, IoT, blockchain, and novel materials. The inventive concept's use of machine learning algorithms, blockchain technology, and AI-powered ultrasound controllers provides a significant improvement over the original patent's method.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different types of AI algorithms, such as reinforcement learning or natural language processing, or the incorporation of additional sensors or data sources to enhance the precision of the sonogenic stimulation method. Variations of the inventive concept may also include the use of different types of nanoparticles or ultrasound-responsive materials.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the treatment of neurological disorders such as Parkinson's disease, epilepsy, and depression. The market for neurological disorder treatments is projected to grow significantly in the coming years, and the inventive concept's ability to provide personalized and effective therapies positions it for success in this market.

Original Patent Information

Patent NumberUS 11,857,809
TitleSonogenic stimulation of cells
Assignee(s)Salk Institute for Biological Studies