Synergistic Sonogenic Stimulation Systems

Publication ID: 24-11857809_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Sonogenic Stimulation Systems,” Published Technical Disclosure No. 24-11857809_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857809_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,809.

Summary of the Inventive Concept

The present inventive concept integrates sonogenic stimulation with AI, IoT, blockchain, and novel materials to create more effective and personalized therapies for neurological disorders.

Background and Problem Solved

The original patent disclosed a method for altering neuron function using sonogenic stimulation. However, the method had limitations in terms of precision, efficacy, and data management. The present inventive concept addresses these limitations by incorporating advanced technologies to enhance the sonogenic stimulation method.

Detailed Description of the Inventive Concept

The inventive concept encompasses four main embodiments. The first embodiment is a system that combines a neuron-specific TRP-4 polypeptide expression vector with an ultrasound transducer and a machine learning algorithm for predicting optimal ultrasound stimulation parameters. The second embodiment is a method that uses blockchain technology to securely store and analyze neuron activity data in conjunction with sonogenic stimulation. The third embodiment is a composition that incorporates a TRP-4 polypeptide, an ultrasound-responsive nanoparticle, and an AI-powered ultrasound controller for real-time optimization of ultrasound stimulation parameters. The fourth embodiment is a non-invasive system that utilizes a wearable IoT device for transmitting ultrasound energy and a cloud-based AI platform for analyzing neuron activity data and providing personalized treatment recommendations. The inventive concept also contemplates the use of synergistic combinations of ultrasound and other stimulation modalities, optimized using deep learning algorithms.

Novelty and Inventive Step

The present inventive concept is novel and non-obvious in its integration of sonogenic stimulation with advanced technologies such as AI, IoT, blockchain, and novel materials. The inventive concept's use of machine learning algorithms, blockchain technology, and AI-powered ultrasound controllers provides a significant improvement over the original patent's method.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different types of AI algorithms, such as reinforcement learning or natural language processing, or the incorporation of additional sensors or data sources to enhance the precision of the sonogenic stimulation method. Variations of the inventive concept may also include the use of different types of nanoparticles or ultrasound-responsive materials.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the treatment of neurological disorders such as Parkinson's disease, epilepsy, and depression. The market for neurological disorder treatments is projected to grow significantly in the coming years, and the inventive concept's ability to provide personalized and effective therapies positions it for success in this market.

Field of Art

Neuroscience, biomedical engineering, and molecular biology, with expertise in neural stimulation techniques, genetic modification of neurons, and ultrasound-based cellular manipulation

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in neuroscience or bioengineering, familiar with genetic modification techniques, ultrasound technologies, and computational approaches to neural stimulation

Obviousness Rationale

A person of ordinary skill would recognize that integrating computational technologies with the source patent's sonogenic stimulation method represents a predictable extension of existing neural manipulation techniques. The core ultrasound-based neuronal stimulation method remains fundamentally unchanged, with added computational layers that a skilled practitioner would view as standard optimization approaches. The PTD's variations primarily represent well-known technological augmentations to an existing precise neurological intervention method.

Obvious Combinations & Variations

Source Patent Element
Ultrasound-sensitive TRP-4 polypeptide for neuronal stimulation
PTD Variation
Adding machine learning algorithms to predict optimal ultrasound stimulation parameters
Obviousness Reasoning
Computational optimization of biological interventions is a standard approach in biomedical engineering, representing a predictable application of known machine learning techniques to an existing neurological stimulation method
Source Patent Element
Ultrasound transducer for targeting specific neurons
PTD Variation
Incorporating IoT and wearable device technologies for ultrasound delivery
Obviousness Reasoning
Miniaturization and remote delivery of medical technologies are well-established trends, making the integration of wearable ultrasound devices an obvious technological progression
Source Patent Element
Genetic modification of neurons for ultrasound sensitivity
PTD Variation
Using blockchain for secure storage and analysis of neuronal activity data
Obviousness Reasoning
Data security and advanced computational tracking are standard considerations in medical technologies, representing a straightforward extension of existing data management practices
Source Patent Element
Ultrasound-based neuronal stimulation method
PTD Variation
Combining ultrasound with AI-powered real-time parameter optimization
Obviousness Reasoning
Adaptive, real-time optimization is a standard approach in precision medical interventions, representing a predictable application of computational technologies to existing stimulation methods
Source Patent Element
Targeted neuronal stimulation using ultrasound
PTD Variation
Implementing deep learning algorithms to optimize multi-modal stimulation approaches
Obviousness Reasoning
Computational approaches to combining therapeutic modalities are well-established in biomedical research, representing a logical and predictable technological progression
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857809 and the published technical disclosure, a person of ordinary skill in the art would find the proposed variations obvious and predictable extensions of existing sonogenic stimulation technologies. The integration of computational, IoT, and AI technologies with established ultrasound-based neuronal manipulation methods represents a straightforward and expected technological progression that does not rise to the level of non-obvious innovation.

Original Patent Information

Patent NumberUS 11,857,809
TitleSonogenic stimulation of cells
Assignee(s)Salk Institute for Biological Studies