Synergistic Ultrasound-Neuron Stimulation Systems

Publication ID: 24-11857809_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Ultrasound-Neuron Stimulation Systems,” Published Technical Disclosure No. 24-11857809_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857809_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,809.

Summary of the Inventive Concept

A novel approach integrating ultrasound-based neuron stimulation with advanced technologies such as AI, IoT, blockchain, and new materials to create a more powerful and effective system for altering neuron function or activity in mammalian subjects.

Background and Problem Solved

The original patent disclosed a method for altering neuron function or activity using ultrasound energy. However, the original method had limitations in terms of data analysis, storage, and real-time optimization. The new inventive concept addresses these limitations by incorporating advanced technologies to enhance the ultrasound-based neuron stimulation system.

Detailed Description of the Inventive Concept

The new inventive concept comprises an ultrasound stimulation device, a blockchain-based data storage module, and a machine learning algorithm for analyzing neuron activity patterns. The ultrasound stimulation device applies ultrasound energy to a targeted tissue portion of a mammalian subject, while the machine learning algorithm is trained to identify optimal ultrasound stimulation parameters for altering neuron function or activity. The blockchain-based data storage module ensures secure, decentralized storage and sharing of neuron activity data. Additionally, the system can be integrated with IoT-enabled sensor modules and cloud-based data analytics platforms for real-time analysis and feedback. Furthermore, the system can utilize novel, ultrasound-sensitive nanomaterials for targeted delivery of ultrasound energy to neurons.

Novelty and Inventive Step

The new claims introduce a synergistic combination of ultrasound-based neuron stimulation with advanced technologies, which is not disclosed in the original patent. The integration of AI, IoT, blockchain, and new materials provides a non-obvious solution to the limitations of the original method, enabling real-time optimization, secure data storage, and improved treatment outcomes.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include variations in the type of advanced technology integrated with the ultrasound-based neuron stimulation system, such as using different AI algorithms or IoT protocols. Additionally, the system could be adapted for use in different mammalian subjects or for treating various neurological disorders.

Potential Commercial Applications and Market

The synergistic ultrasound-neuron stimulation system has significant commercial potential in the fields of neuroscience, neurology, and biomedical engineering. The system could be used to develop new treatments for neurological disorders, such as Parkinson's disease, epilepsy, or chronic pain. The market for such a system is substantial, with potential applications in hospitals, research institutions, and pharmaceutical companies.

Field of Art

Neuroscience, biomedical engineering, and neural interface technologies with expertise in ultrasound-based cellular stimulation, genetic modification of neural receptors, and advanced signal processing techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in neuroscience or bioengineering, familiar with ultrasound technologies, neural stimulation methods, machine learning applications in medical technologies, and interdisciplinary approaches to neural interface design

Obviousness Rationale

A person skilled in the art would recognize that integrating machine learning, IoT, and blockchain technologies with ultrasound-based neuron stimulation represents a predictable extension of existing neural interface technologies. The source patent establishes a foundational method of ultrasound-based neuron modulation, which naturally invites technological enhancements using contemporary computational and data management approaches. The PTD's variations demonstrate standard engineering problem-solving by applying known technologies to improve neural stimulation systems.

Obvious Combinations & Variations

Source Patent Element
Ultrasound energy application for neuron stimulation using specific transmembrane proteins
PTD Variation
Machine learning algorithm for optimizing ultrasound stimulation parameters
Obviousness Reasoning
Predictable application of AI optimization techniques to improve precision of existing neural stimulation methods, representing a known approach in biomedical engineering for refining therapeutic interventions
Source Patent Element
Targeted tissue portion stimulation using ultrasound transducer
PTD Variation
IoT-enabled sensor modules for real-time neuron activity monitoring and feedback
Obviousness Reasoning
Routine technological enhancement using standard IoT integration techniques to provide continuous monitoring and adaptive stimulation, which would be an obvious improvement to existing neural interface technologies
Source Patent Element
Genetic modification of neurons to express ultrasound-sensitive proteins
PTD Variation
Ultrasound-sensitive nanomaterials for targeted energy delivery
Obviousness Reasoning
Logical progression in materials science to improve targeting and efficiency of neural stimulation, representing an expected innovation by combining known approaches in nanotechnology and neural interface design
Source Patent Element
Method for altering neuron function through external energy application
PTD Variation
Blockchain-based secure data storage and sharing of neuron activity data
Obviousness Reasoning
Standard data management approach for medical technologies, representing an obvious solution for secure, decentralized tracking of neural stimulation research and clinical data
35 U.S.C. § 103 Summary: Based on US Patent 11857809's disclosure of ultrasound-based neuron stimulation methods, the present publication demonstrates that integrating machine learning, IoT, blockchain, and advanced materials technologies represents an obvious variation to a person having ordinary skill in neural interface design, thereby establishing prior art that would render obvious subsequent claims attempting to monopolize these technological combinations.

Original Patent Information

Patent NumberUS 11,857,809
TitleSonogenic stimulation of cells
Assignee(s)Salk Institute for Biological Studies