Synergistic Ultrasound-Neuron Stimulation Systems

Publication ID: 24-11857809_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Ultrasound-Neuron Stimulation Systems,” Published Technical Disclosure No. 24-11857809_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857809_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,809.

Summary of the Inventive Concept

A novel approach integrating ultrasound-based neuron stimulation with advanced technologies such as AI, IoT, blockchain, and new materials to create a more powerful and effective system for altering neuron function or activity in mammalian subjects.

Background and Problem Solved

The original patent disclosed a method for altering neuron function or activity using ultrasound energy. However, the original method had limitations in terms of data analysis, storage, and real-time optimization. The new inventive concept addresses these limitations by incorporating advanced technologies to enhance the ultrasound-based neuron stimulation system.

Detailed Description of the Inventive Concept

The new inventive concept comprises an ultrasound stimulation device, a blockchain-based data storage module, and a machine learning algorithm for analyzing neuron activity patterns. The ultrasound stimulation device applies ultrasound energy to a targeted tissue portion of a mammalian subject, while the machine learning algorithm is trained to identify optimal ultrasound stimulation parameters for altering neuron function or activity. The blockchain-based data storage module ensures secure, decentralized storage and sharing of neuron activity data. Additionally, the system can be integrated with IoT-enabled sensor modules and cloud-based data analytics platforms for real-time analysis and feedback. Furthermore, the system can utilize novel, ultrasound-sensitive nanomaterials for targeted delivery of ultrasound energy to neurons.

Novelty and Inventive Step

The new claims introduce a synergistic combination of ultrasound-based neuron stimulation with advanced technologies, which is not disclosed in the original patent. The integration of AI, IoT, blockchain, and new materials provides a non-obvious solution to the limitations of the original method, enabling real-time optimization, secure data storage, and improved treatment outcomes.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include variations in the type of advanced technology integrated with the ultrasound-based neuron stimulation system, such as using different AI algorithms or IoT protocols. Additionally, the system could be adapted for use in different mammalian subjects or for treating various neurological disorders.

Potential Commercial Applications and Market

The synergistic ultrasound-neuron stimulation system has significant commercial potential in the fields of neuroscience, neurology, and biomedical engineering. The system could be used to develop new treatments for neurological disorders, such as Parkinson's disease, epilepsy, or chronic pain. The market for such a system is substantial, with potential applications in hospitals, research institutions, and pharmaceutical companies.

Original Patent Information

Patent NumberUS 11,857,809
TitleSonogenic stimulation of cells
Assignee(s)Salk Institute for Biological Studies