Next-Generation Sonogenic Stimulation for Neural Circuit Modulation
Legal Citation
Summary of the Inventive Concept
A system and method for modulating neural circuits using ultrasound, enabling targeted and spatially-precise control of neural activity, with potential applications in treating neurological disorders and enhancing cognitive function.
Background and Problem Solved
The original patent disclosed a method for altering neural activity using ultrasound, but had limitations in terms of spatial resolution and specificity. The new inventive concept addresses these limitations by introducing a micro-TRP4 expression vector for spatially-targeted expression of TRP4 polypeptides, enabling more precise control of neural activity.
Detailed Description of the Inventive Concept
The new inventive concept comprises a neural interface device, a micro-TRP4 expression vector, and an ultrasound transducer array. The micro-TRP4 expression vector is configured to express TRP4 polypeptides in a spatially-targeted manner within the neural circuit, allowing for precise control of neural activity. The ultrasound transducer array applies ultrasound energy to the targeted tissue portion, stimulating the TRP4-expressing neurons. The system can be used to modulate neural circuits, generate neural maps, and treat neurological disorders.
Novelty and Inventive Step
The new claims introduce the concept of spatially-targeted expression of TRP4 polypeptides using a micro-TRP4 expression vector, which is not disclosed in the original patent. This enables more precise control of neural activity and represents a significant advancement over the original invention.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different ultrasound frequencies, pulse durations, or spatial patterns to modulate neural activity. Additionally, the system could be adapted for use in other applications, such as neural prosthetics or brain-computer interfaces.
Potential Commercial Applications and Market
The inventive concept has potential applications in the treatment of neurological disorders, such as Parkinson's disease, epilepsy, and depression, as well as in enhancing cognitive function. The market for neural modulation technologies is rapidly growing, with an estimated value of $10 billion by 2025.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Neuroscience and biomedical engineering, with expertise in neural stimulation techniques, genetic engineering of neural circuits, and ultrasound-based cellular modulation
Person of Ordinary Skill (PHOSITA) Profile
A researcher with advanced training in neurobiology, genetic engineering, and biomedical instrumentation, capable of understanding complex neural stimulation techniques and genetic modification strategies
Obviousness Rationale
A person of ordinary skill would recognize that the PTD represents a predictable extension of the source patent's core ultrasound neural stimulation technique by introducing spatially-targeted genetic expression and expanded application domains. The fundamental mechanism of ultrasound-mediated neural modulation remains consistent, with the PTD simply refining the approach through more precise genetic targeting and novel application contexts. These variations represent logical incremental improvements that would be apparent to a skilled practitioner familiar with neural engineering and genetic manipulation techniques.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,809 |
|---|---|
| Title | Sonogenic stimulation of cells |
| Assignee(s) | Salk Institute for Biological Studies |