Ultrasound Technology for Diverse Dermatological Applications

Publication ID: 24-11857812_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Ultrasound Technology for Diverse Dermatological Applications,” Published Technical Disclosure No. 24-11857812_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857812_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,812.

Summary of the Inventive Concept

This inventive concept leverages the core technology of ultrasound-guided opening of the blood-brain barrier to develop novel treatments for various skin conditions, hair loss, wound healing, and acne, enabling targeted and effective delivery of therapeutic agents.

Background and Problem Solved

The original patent disclosed a system for ultrasound-guided opening of the blood-brain barrier, addressing the challenge of delivering therapeutic agents across this selective barrier. However, this technology has broader potential applications in dermatology, where targeted delivery of agents can significantly enhance treatment outcomes. The inventive concept solves the problem of limited transdermal delivery and ineffective treatment of skin conditions by adapting the ultrasound technology to create temporary pores in the skin, enabling efficient delivery of cosmetic and therapeutic agents.

Detailed Description of the Inventive Concept

The inventive concept comprises a skin analysis module, an ultrasound transducer, and a control module. The skin analysis module identifies areas of skin requiring treatment, while the ultrasound transducer delivers ultrasound energy to create temporary pores in the skin. The control module coordinates the delivery of ultrasound energy with the application of therapeutic agents. This enables targeted and effective treatment of skin conditions, hair loss, wound healing, and acne. The system can be adapted for various dermatological applications by modifying the skin analysis module, ultrasound transducer, and control module to accommodate specific treatment requirements.

Novelty and Inventive Step

The inventive concept introduces a new application of ultrasound technology, moving beyond the original patent's focus on the blood-brain barrier to address unmet needs in dermatology. The novel combination of skin analysis, ultrasound energy delivery, and coordinated therapeutic agent application constitutes an inventive step, as it enables targeted and effective treatment of diverse skin conditions.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include varying the frequency and intensity of ultrasound energy, incorporating additional sensors or imaging modalities for skin analysis, or integrating the system with existing dermatological treatment devices. Variations of the system could also be developed for specific skin conditions, such as psoriasis or eczema, or for use in cosmetic applications, such as skin rejuvenation or tattoo removal.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the dermatology and cosmetic industries, with a large addressable market for treatments of skin conditions, hair loss, wound healing, and acne. The system's ability to enhance transdermal delivery and enable targeted treatment of skin conditions could disrupt traditional treatment approaches, offering a competitive advantage to companies adopting this technology.

Field of Art

Medical ultrasound technology with expertise in targeted energy delivery and transdermal therapeutic applications, requiring advanced understanding of ultrasound physics, medical imaging, and targeted drug/agent delivery mechanisms

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device researcher with advanced degrees, familiar with ultrasound transducer technologies, therapeutic energy delivery techniques, and interdisciplinary medical treatment approaches

Obviousness Rationale

The PTD represents a straightforward extension of the source patent's core ultrasound energy delivery technology by applying the fundamental principles of targeted ultrasound-induced tissue permeability to dermatological applications. A PHOSITA would recognize that the precise control of ultrasound energy for creating temporary tissue pores is directly transferable between neurological and dermatological contexts. The systematic approach of using ultrasound to create temporary permeability for targeted agent delivery remains conceptually consistent across different tissue types.

Obvious Combinations & Variations

Source Patent Element
Ultrasound transducer with plurality of treatment elements capable of precise energy delivery
PTD Variation
Skin-targeted ultrasound transducer for creating temporary dermal pores
Obviousness Reasoning
Known technique of adapting ultrasound energy delivery across tissue types with predictable results of controlled permeability
Source Patent Element
Data processor for monitoring and adjusting ultrasound transducer positioning
PTD Variation
Skin analysis module for identifying and targeting specific dermatological treatment areas
Obviousness Reasoning
Predictable application of existing positioning and targeting algorithms to a new medical domain
Source Patent Element
Method of opening biological barriers for therapeutic agent delivery
PTD Variation
Transdermal delivery of cosmetic and therapeutic agents through ultrasound-induced temporary pores
Obviousness Reasoning
Finite and obvious extension of known ultrasound permeability techniques to alternative tissue types and treatment modalities
Source Patent Element
Robotic manipulator for precise ultrasound transducer positioning
PTD Variation
Control module coordinating ultrasound energy delivery with topical agent application
Obviousness Reasoning
Logical combination of existing precise energy delivery technologies with targeted treatment approaches
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857812 regarding ultrasound-guided tissue permeability, the present publication demonstrates that a person having ordinary skill in the art would find the disclosed dermatological ultrasound applications obvious and non-inventive. The systematic adaptation of ultrasound energy delivery principles to create temporary tissue permeability represents a predictable variation within the existing technological framework, thereby rendering potential derivative claims obvious and anticipatable as a matter of standard technological progression.

Original Patent Information

Patent NumberUS 11,857,812
TitleUltrasound guided opening of blood-brain barrier
Assignee(s)Cordance Medical Inc.