Synergistic Blood-Brain Barrier Opening Systems
Legal Citation
Summary of the Inventive Concept
A novel system integrating ultrasound technology with AI, IoT, blockchain, and nanomaterials to selectively open the blood-brain barrier for enhanced drug delivery to the brain.
Background and Problem Solved
The original patent for ultrasound guided opening of the blood-brain barrier has limitations in terms of real-time monitoring, personalized treatment, and secure data storage. The new inventive concept addresses these limitations by integrating distinct technologies to create a more powerful system.
Detailed Description of the Inventive Concept
The system consists of an ultrasound treatment module, an AI-powered image analysis module, an IoT-enabled ultrasound device, a blockchain-based data storage module, and a nanomaterial-based ultrasound contrast agent. The AI module identifies optimal target regions for ultrasound energy delivery based on real-time patient data and previously acquired images. The IoT device communicates with a cloud-based server to access a database of optimal treatment protocols. The blockchain-based module securely stores and accesses patient-specific data and treatment protocols. The nanomaterial-based ultrasound contrast agent is selectively targeted to the blood-brain barrier, enhancing drug delivery to the brain.
Novelty and Inventive Step
The new inventive concept is novel and non-obvious in its integration of AI, IoT, blockchain, and nanomaterials with ultrasound technology to create a synergistic system for selectively opening the blood-brain barrier. The inventive step lies in the combination of these distinct technologies to achieve enhanced drug delivery to the brain.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different AI algorithms, IoT protocols, blockchain architectures, or nanomaterials. Variations could also include the integration of additional technologies, such as machine learning or robotics, to further enhance the system's capabilities.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the pharmaceutical and medical device industries, particularly in the treatment of brain cancers and other diseases affecting the brain. The market for this technology is substantial, with potential applications in hospitals, clinics, and research institutions.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Medical imaging, ultrasound technology, neurological intervention techniques with specific expertise in blood-brain barrier manipulation and targeted drug delivery systems
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or medical device researcher with advanced degrees in bioengineering, electrical engineering, or medical physics, possessing knowledge of ultrasound technologies, medical imaging, neurological interventions, and emerging digital health technologies
Obviousness Rationale
A PHOSITA would recognize that integrating AI, IoT, blockchain, and nanomaterial technologies with existing ultrasound-guided blood-brain barrier opening techniques represents a predictable combination of known technologies to achieve enhanced medical intervention. The source patent establishes the foundational ultrasound treatment methodology, while the PTD demonstrates straightforward technological augmentations using standard engineering design approaches. These variations represent incremental improvements using readily available technological components within a well-established medical intervention framework.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,812 |
|---|---|
| Title | Ultrasound guided opening of blood-brain barrier |
| Assignee(s) | Cordance Medical Inc. |