Next-Generation High-Intensity Focused Ultrasound Systems for Tissue Treatment
Legal Citation
Summary of the Inventive Concept
A novel high-intensity focused ultrasound system capable of selectively disrupting fibrous structures of an extracellular matrix while preserving cellular structures, enabling advanced tissue treatment and regeneration.
Background and Problem Solved
The original patent's high-intensity focused ultrasound systems have limitations in selectively targeting tissue structures. The new inventive concept addresses this limitation by introducing a three-dimensional ultrasound field and dynamic adjustment capabilities, allowing for more precise and effective tissue treatment.
Detailed Description of the Inventive Concept
The next-generation high-intensity focused ultrasound system comprises a phased array transducer configured to generate a three-dimensional ultrasound field, and a controller or machine learning module operably coupled to the transducer. The controller or machine learning module dynamically adjusts the ultrasound field to selectively disrupt fibrous structures of an extracellular matrix while preserving cellular structures in a target site. This is achieved through the generation of shock waves, cavitation bubbles, or other mechanisms that can be optimized for specific tissue types and treatment goals.
Novelty and Inventive Step
The new inventive concept's use of a three-dimensional ultrasound field and dynamic adjustment capabilities, combined with the selective disruption of fibrous structures while preserving cellular structures, constitutes a novel and non-obvious advancement over the original patent.
Alternative Embodiments and Variations
Alternative embodiments may include the use of different transducer geometries, ultrasound frequencies, or machine learning algorithms to optimize the system for various tissue types and treatment applications. Variations may also include the integration of additional sensors or imaging modalities to enhance treatment precision and monitoring.
Potential Commercial Applications and Market
The next-generation high-intensity focused ultrasound system has significant commercial potential in the fields of regenerative medicine, cancer treatment, and cosmetic surgery, with potential applications in tissue engineering, wound healing, and other areas where precise tissue manipulation is required.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Medical ultrasound technology, specifically high-intensity focused ultrasound (HIFU) systems for tissue treatment, requiring expertise in biomedical engineering, ultrasound physics, and medical device design
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or medical device researcher with advanced degrees in bioengineering or medical physics, experienced in ultrasound technology, signal processing, and tissue interaction mechanisms
Obviousness Rationale
A PHOSITA would recognize that the PTD's three-dimensional ultrasound field and dynamic adjustment capabilities represent predictable extensions of the source patent's core HIFU technology. The selective disruption of extracellular matrix structures builds directly on the existing shock wave and cavitation techniques disclosed in the original patent. The addition of machine learning for parameter optimization would be a natural progression for a skilled practitioner seeking to enhance treatment precision.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,813 |
|---|---|
| Title | High intensity focused ultrasound systems for treating tissue |
| Assignee(s) | University of Washington |