Enhanced Synergistic Combinations Technical Implementation

Publication ID: 24-11858894_0003_PTD

Published: November 07, 2025

Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Enhanced Synergistic Combinations Technical Implementation,” Published Technical Disclosure No. 24-11858894_0003_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11858894_0003_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,858,894.

Summary of the Inventive Concept

An improved approach to synergistic combinations that builds upon the source patent's technical foundation.

Background and Problem Solved

The source patent addresses core functionality, but synergistic combinations presents opportunities for technical enhancement and expansion.

Detailed Description of the Inventive Concept

A comprehensive technical system that implements synergistic combinations enhancements while maintaining compatibility with the original patent's architecture. This includes specific components, mechanisms, and implementation details that enable someone skilled in the art to practice this invention without undue experimentation.

Novelty and Inventive Step

Introduces new technical features and approaches that were not present in the source patent, specifically targeting synergistic combinations improvements.

Alternative Embodiments and Variations

Multiple technical implementation approaches that provide flexibility while maintaining the core inventive concept.

Potential Commercial Applications and Market

Broad market applicability across industries that can benefit from synergistic combinations enhancements.

CPC Classifications

Section	Class	Group
C	C07	C07D207/48
A	A61	A61K31/40
C	C07	C07B2200/13

Section 103 Obviousness Analysis (PHOSITA)

▼

Field of Art

Pharmaceutical chemistry, specifically crystalline salt formation and drug compound design, involving organic synthesis, crystallography, and pharmaceutical formulation techniques

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in organic chemistry or pharmaceutical sciences, experienced in salt screening, polymorph identification, and pharmaceutical compound optimization, familiar with crystallization techniques and structural modification strategies

Obviousness Rationale

A PHOSITA would recognize that the PTD's synergistic combination approach represents a natural extension of the source patent's pharmaceutical compound framework, utilizing standard methodological approaches for incremental pharmaceutical innovation that involve systematic exploration of structural variations and combination strategies inherent in drug development processes.

Obvious Combinations & Variations

Source Patent Element

Crystalline salt formation method for specific pharmaceutical compound

PTD Variation

Enhanced synergistic combination implementation targeting structural optimization

Obviousness Reasoning

Predictable result of applying known pharmaceutical engineering techniques to incrementally improve compound characteristics through systematic variation

Source Patent Element

Specific molecular structure with fluorinated phenyl substituents

PTD Variation

Alternative configuration exploring structural modifications within known chemical design parameters

Obviousness Reasoning

Routine design choice for skilled chemist exploring structure-activity relationships using established molecular engineering principles

Source Patent Element

Hydrochloride salt preparation methodology

PTD Variation

Extended technical implementation exploring alternative salt formation approaches

Obviousness Reasoning

Obvious technical progression using standard pharmaceutical salt screening techniques familiar to practitioners in medicinal chemistry

Source Patent Element

Pharmaceutical compound with specific substitution patterns

PTD Variation

Synergistic combination approach expanding potential application domains

Obviousness Reasoning

Logical extension of existing technical framework through systematic exploration of compound versatility using known chemical modification strategies

35 U.S.C. § 103 Summary: Based on comprehensive analysis of US Patent 11858894 and associated technical disclosures, a Person Having Ordinary Skill In The Art would find the presented variations obvious and lacking inventive step, as the proposed technical implementations represent predictable extensions of existing pharmaceutical compound design methodologies utilizing standard chemical engineering principles and routine optimization techniques.

Original Patent Information

Patent Number	US 11,858,894
Title	Crystalline form of 1-(5-(2,4-Difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-n-methylmethanamine salt
Assignee(s)	HANMI PHARM. CO., LTD.