Enhanced Synergistic Combinations Technical Implementation

Publication ID: 24-11858904_0003_PTD

Published: November 07, 2025

Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Enhanced Synergistic Combinations Technical Implementation,” Published Technical Disclosure No. 24-11858904_0003_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11858904_0003_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,858,904.

Summary of the Inventive Concept

An improved approach to synergistic combinations that builds upon the source patent's technical foundation.

Background and Problem Solved

The source patent addresses core functionality, but synergistic combinations presents opportunities for technical enhancement and expansion.

Detailed Description of the Inventive Concept

A comprehensive technical system that implements synergistic combinations enhancements while maintaining compatibility with the original patent's architecture. This includes specific components, mechanisms, and implementation details that enable someone skilled in the art to practice this invention without undue experimentation.

Novelty and Inventive Step

Introduces new technical features and approaches that were not present in the source patent, specifically targeting synergistic combinations improvements.

Alternative Embodiments and Variations

Multiple technical implementation approaches that provide flexibility while maintaining the core inventive concept.

Potential Commercial Applications and Market

Broad market applicability across industries that can benefit from synergistic combinations enhancements.

CPC Classifications

Section	Class	Group
C	C07	C07D261/04
A	A01	A01N43/80
C	C07	C07B2200/13

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Chemical engineering and pharmaceutical compositions, specifically focused on particle engineering for isoxazoline compounds with expertise in particle size manipulation, dispersion techniques, and antiparasitic formulation technologies

Person of Ordinary Skill (PHOSITA) Profile

A chemical engineer or pharmaceutical formulation specialist with advanced degree, 3-5 years industrial experience in particle engineering, knowledge of static light scattering techniques, scanning electron microscopy, and particulate material characterization methods

Obviousness Rationale

A skilled practitioner would recognize that the PTD's synergistic combination approach represents a natural extension of the source patent's foundational particle engineering techniques. The disclosed variations demonstrate incremental improvements that would be predictable to someone familiar with isoxazoline compound formulation strategies. The technical implementation builds upon known particle size and distribution principles while introducing modest enhancements that do not require inventive leap.

Obvious Combinations & Variations

Source Patent Element

Isoxazoline compound particle composition with specific volume weighted particle size distribution

PTD Variation

Enhanced synergistic combination system targeting particle interaction and distribution optimization

Obviousness Reasoning

Predictable variation using known particle engineering techniques to improve compound performance, representing standard design optimization approach

Source Patent Element

Particle size measurement using static light scattering instrument

PTD Variation

Advanced measurement techniques incorporating multi-dimensional particle characterization

Obviousness Reasoning

Known instrumentation enhancement representing standard technological progression in measurement capabilities

Source Patent Element

Particle thickness greater than 10 μm as measured by scanning electron microscopy

PTD Variation

Refined particle morphology control strategies with enhanced dimensional precision

Obviousness Reasoning

Routine materials engineering approach to incrementally improving particle structural characteristics using established characterization methods

Source Patent Element

Antiparasitic compound formulation techniques

PTD Variation

Expanded synergistic combination methodology for improved compound interaction

Obviousness Reasoning

Logical extension of existing formulation knowledge applying standard pharmaceutical engineering principles

Source Patent Element

Particle size distribution maintenance under varying dispersion pressures

PTD Variation

Dynamic particle interaction modeling with enhanced stability parameters

Obviousness Reasoning

Predictable technical improvement representing standard scientific approach to understanding material behavior under controlled conditions

35 U.S.C. § 103 Summary: Based on comprehensive analysis of US Patent 11858904 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations obvious and lacking inventive step. The incremental technical improvements represent predictable extensions of existing particle engineering knowledge, thereby rendering potential derivative claims obvious under 35 U.S.C. Section 103 standard of non-obviousness.

Original Patent Information

Patent Number	US 11,858,904
Title	Process for preparing large size isoxazoline particles
Assignee(s)	Intervet Inc.